|
Symbol Name ID |
Tfam
transcription factor A, mitochondrial MGI:107810 |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyposmia |
Dysphagia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Gliosis |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Cerebellar atrophy |
Neurodegeneration |
Neuronal loss in central nervous system |
Gait ataxia |
Bradykinesia |
Chorea |
Fasciculations |
Tremor |
Paralysis |
Babinski sign |
Dysarthria |
Language impairment |
Depression |
Emotional lability |
Anxiety |
Panic attack |
Hallucinations |
Atypical behavior |
Apathy |
Lethargy |
Reduced social reciprocity |
Personality changes |
Impulsivity |
Agitation |
Restless legs |
Cognitive impairment |
Dementia |
Frontal lobe dementia |
Frontotemporal dementia |
Short attention span |
Sleep abnormality |
Insomnia |
Hyperreflexia |
Jaw hyperreflexia |
Dyskinesia |
Dystonia |
Gait imbalance |
Postural instability |
Seizure |
Abnormal autonomic nervous system physiology |
| Disease(s) Associated with TFAM | |||||||||||||||||||||||||||||||||||||||||||||||||
| amyotrophic lateral sclerosis | |||||||||||||||||||||||||||||||||||||||||||||||||
| Huntington's disease | |||||||||||||||||||||||||||||||||||||||||||||||||
| mitochondrial DNA depletion syndrome 15 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Parkinson's disease |
| Mouse Phenotypes | decreased neuron mitochondrial DNA content |
abnormal enteric neuron morphology |
abnormal PNS glial cell morphology |
gliosis |
abnormal dopaminergic neuron morphology |
loss of dopaminergic neurons |
decreased neuron number |
neuron degeneration |
neuronal intranuclear inclusions |
absent optic nerve |
neurodegeneration |
axon degeneration |
abnormal nervous system physiology |
|
| Availability | Mouse Genotype | |||||||||||||
| Tfamtm1.1Lrsn/Tfamtm1.1Lrsn | ||||||||||||||
| Tfamtm1Lrsn/Tfamtm1Lrsn Tg(Camk2a-cre)1Lfr/0 (conditional) |
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| Slc6a3tm1(cre)Lrsn/Slc6a3+ Tfamtm1Lrsn/Tfamtm1Lrsn (conditional) |
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| Cnptm1(cre)Kan/Cnp+ Tfamtm1Lrsn/Tfamtm1Lrsn (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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